This paper encompasses an in-depth examination of Retinopathy of Prematurity (ROP) diagnosis, employing advanced deep learning methodologies. Our focus centers on refining and evaluating CNN-based approaches for precise and efficient ROP detection. We navigate the complexities of dataset curation, preprocessing strategies, and model architecture, aligning with research objectives encompassing model effectiveness, computational cost analysis, and time complexity assessment. Results underscore the supremacy of tailored CNN models over pre-trained counterparts, evident in heightened accuracy and F1-scores. Implementation of a voting system further enhances performance. Additionally, our study reveals the potential of the proposed customized CNN model to alleviate computational burdens associated with deep neural networks. Furthermore, we showcase the feasibility of deploying these models within dedicated software and hardware configurations, highlighting their utility as valuable diagnostic aids in clinical settings. In summary, our discourse significantly contributes to ROP diagnosis, unveiling the efficacy of deep learning models in enhancing diagnostic precision and efficiency.

Vessel structure is one of the most important parts of the retina which physicians can detect many diseases by analysing its features. Localization of blood vessels in retina images is an important process in medical image analysis. This process is also more challenging with the presence of bright and dark lesions. In this thesis, two automated vessel localization methods to handle both healthy and unhealthy (pathological) retina images are analyzed. Each method consists of two major steps and the second step is the same in the two methods. In the first step, an algorithm is used to decrease the effect of bright lesions. In Method 1, this algorithm is based on K- Means segmentation, and in Method 2, it is based on a regularization procedure. In the second step of both methods, a multi-scale line operator is used to localize the line-shaped vascular structures and ignore the dark lesions which are generally assumed to have irregular patterns. After the introduction of the methods, a detailed quantitative and qualitative comparison of the methods with one another as well as the state-of-the-art solutions in the literature based on the segmentation results on the images of the two publicly available datasets, DRIVE and STARE, is reported. The results demonstrate that the methods are highly comparable with other solutions.

Deep learning-based models are developed to automatically detect if a retina image is `referable' in diabetic retinopathy (DR) screening. However, their classification accuracy degrades as the input images distributionally shift from their training distribution. Further, even if the input is not a retina image, a standard DR classifier produces a high confident prediction that the image is `referable'. Our paper presents a Dirichlet Prior Network-based framework to address this issue. It utilizes an out-of-distribution (OOD) detector model and a DR classification model to improve generalizability by identifying OOD images. Experiments on real-world datasets indicate that the proposed framework can eliminate the unknown non-retina images and identify the distributionally shifted retina images for human intervention.

In this project, we developed a deep learning system applied to human retina images for medical diagnostic decision support. The retina images were provided by EyePACS (Eyepacs, LLC). These images were used in the framework of a Kaggle contest (Kaggle INC, 2017), whose purpose to identify diabetic retinopathy signs through an automatic detection system. Using as inspiration one of the solutions proposed in the contest, we implemented a model that successfully detects diabetic retinopathy from retina images. After a carefully designed preprocessing, the images were used as input to a deep convolutional neural network (CNN). The CNN performed a feature extraction process followed by a classification stage, which allowed the system to differentiate between healthy and ill patients using five categories. Our model was able to identify diabetic retinopathy in the patients with an agreement rate of 76.73% with respect to the medical expert's labels for the test data.

Your eyes might be the perfect windows into your heart. At least, they're windows that Google-created artificial intelligence software can use to calculate your risk factors for heart disease. According to a study recently published in the Nature Biomedical Engineering journal, an AI algorithm created by Google AI and Verily Life Sciences (an Alphabet subsidiary that spun off from Google) can predict whether a patient is likely to suffer a major cardiovascular event like a heart attack or stroke within five years, based on a photo of their retina. So far, the predictions work about as well as presently accepted methods that are more invasive, according to the study. The fact that disease can be spotted in the retina isn't a surprise. To mimic that ability, the Verily and Google researchers trained AI software to identify cardiovascular risks by having the system analyze retina photos and health data from 284,335 patients.